The first case was reported in America at the University of Pennsylvania by Thaxter in 1816, with subsequent cases reported by Peacock (18), Widman (1881), and finally Fallot (1888). Many other cases have been presented by Pulteney (1785), Abernethy (1793), Bell (1797), Dorsey (1812), and Farre (1814). Later in 1782, William Hunter, a Scottish physician, presented to the Society of Physicians in London a case of a 13-year-old boy with tetralogy and blue spells, who was discovered posthumously in 1774, along with three other cases of congenital heart disease. In 1777, Eduard Sandifort, a Dutch physician, reported a case of tetralogy in a 16-month-old patient called “the blue boy.” At first, he was thought to have asthma however, an autopsy revealed a congenitally malformed heart with no signs of ductus arteriosus or ligamentum arteriosum. The discovery of the constellation of findings that hallmark the tetralogy was first described in a short paper titled “Dissection of a Monstrous Foetus in Paris” in 1671, highlighting the unusual form in which the arteries emerge, the narrowing of the pulmonary artery, the absence of the ductus arteriosus, a subaortic interventricular septal defect, an overriding aortic canal common to both ventricles, and the physiology of fetal cardiac circulation describing how blood was redirected directly into the aorta instead of the pulmonary artery.
His work made significant contributions to the field of cardiac anatomy and pathology.
Tetralogy of Fallot (TOF), historically and appropriately referred as Steno-Fallot tetralogy, was first described by the Danish physician/anatomist Dane Niels Stensen, also referenced as Nicoulas Steno in Latin, a pioneer in anatomy and geology.
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